Dementia in a patient with Thymoma and hypogammaglobulinaemia (Good's syndrome)
نویسندگان
چکیده
Good's syndrome is extremely rare and refers to an acquired B and T cell immunodeficiency in thymoma patients. The authors of this article present a case report of a 75-year-old, caucasian male patient previously subjected to examinations for secondary dementia and recurrent infections, which revealed paraneoplastic syndrome arose from thymoma. He underwent thymectomy, while his immunodeficiency syndrome sustained with frequent opportunistic infections, constantly requiring intravenous immunoglobulin treatment.
منابع مشابه
Diagnostic Dilemma: Lymphocytopenia in a Patient with Thymoma – Side Effect due to Irradiation Treatment or Development of Good's Syndrome?
A case of persistent B-cell lymphocytopenia in a 40-year-old woman with lymphoid-epithelial thymoma treated with chemotherapy, surgery and irradiation is described. The possible diagnosis of Good's syndrome (hypogammaglobulinaemia and thymoma) is discussed.
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Thymomas are neoplasias that begin in the thymus and develop in the anterior mediastinum. They are commonly associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, hypogammaglobulinaemia, pancytopaenia, collagen diseases, and, most commonly, myasthenia gravis. The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of ...
متن کاملBeware of the Patient with Thymectomy: Good's Syndrome in a Patient Presenting with Diarrhea
Good's syndrome is a rare cause of immunodeficiency in adults associated with thymoma. We describe an 80-year-old female with chronic diarrhea, multiple opportunistic infections, and cytopenias. She underwent a thymectomy 5 years ago for a thymoma. Laboratory tests revealed neutropenia, hypogammaglobulinaemia, complete B-cell lymphopenia, and low CD4 T cells with inverted CD4:CD8 ratio, which i...
متن کاملWhat is Good's syndrome? Immunological abnormalities in patients with thymoma.
Good’s syndrome (thymoma with immunodeficiency) is a rare cause of combined B and T cell immunodeficiency in adults. The clinical characteristics of Good’s syndrome are increased susceptibility to bacterial infections with encapsulated organisms and opportunistic viral and fungal infections. The most consistent immunological abnormalities are hypogammaglobulinaemia and reduced or absent B cells...
متن کاملImmunological disturbances in Good's syndrome.
BACKGROUND Immunodeficiency with a thymoma (Good's syndrome) is a rare condition occurring in patients with adult-onset hypogammaglobulinaemia. CLINICAL REPORT We describe the case of a 38-yr-old woman with an upper mediastinal mass and inflammatory infiltrations in the lungs. After thymectomy, the patient's condition did not improve. The HRCT scan showed bronchiectasies with parenchymal opac...
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ورودعنوان ژورنال:
- Cases Journal
دوره 1 شماره
صفحات -
تاریخ انتشار 2008